Download 2008 Amendments to the National Academies' Guidelines for by National Research Council, Institute of Medicine, Board on PDF

By National Research Council, Institute of Medicine, Board on Health Sciences Policy, Division on Earth and Life Studies, Board on Life Sciences, Human Embryonic Stem Cell Research Advisory Committee

In 2005, the nationwide Academies published the document guidance for Human Embryonic Stem phone examine, which provided a typical set of moral criteria for a box that, a result of absence of complete federal investment, was once missing nationwide criteria for research.

In order to maintain the information modern, given the quick speed of clinical advancements within the box of stem phone examine, the Human Embryonic Stem telephone study Advisory Committee used to be confirmed in 2006 with help from The Ellison clinical origin, The Greenwall beginning, and the Howard Hughes clinical Institute.

As it did in 2007, the Committee pointed out matters that warranted revision, and this booklet addresses these matters in a moment set of amendments. most significantly, this booklet addresses new medical advancements in reprogramming of somatic cells to pluripotency via including a brand new part and revising different proper sections of the Guidelines.

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Extra info for 2008 Amendments to the National Academies' Guidelines for Human Embryonic Stem Cell Research

Sample text

6(b) “Acceptably derived” means that the cell lines were derived from gametes or embryos for which (i) the donation protocol was reviewed and approved by an IRB or, in the case of donations taking place outside the United States, a substantially equivalent oversight body; (ii) consent to donate was voluntary and informed; (iii) donation was made with reimbursement policies consistent with these Guidelines; and (iv) donation and derivation complied with the extant legal requirements of the relevant jurisdiction.

Ovariectomy—Surgical removal of an ovary. Parthenogenesis—Development in which the embryo contains only maternal chromosomes. Passage—A round of cell growth and proliferation in culture. Phenotype—Visible properties of an organism produced by interaction of genotype and environment. Placenta—The oval or discoid spongy structure in the uterus from which the fetus derives its nourishment and oxygen. Pluripotent cell—A cell that has the capability of developing into cells of all germ layers (endoderm, ectoderm, and mesoderm).

Androgenesis—Development in which the embryo contains only paternal chromosomes. Autologous transplant—Transplanted tissue derived from the intended recipient of the transplant. Such a transplant helps to avoid complications of immune rejection. Blastocoel—The cavity in the center of a blastocyst. Blastocyst—A preimplantation embryo of 50–250 cells depending on age. The blastocyst consists of a sphere made up of an outer layer of cells (the trophectoderm), a fluid-filled cavity (the blastocoel), and a cluster of cells on the interior (the inner cell mass).

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