By Thomas A. Buchholz, Eric A. Strom (auth.), David E. Wazer, Douglas W. Arthur, Frank A. Vicini (eds.)
Accelerated partial breast irradiation (APBI) is being quickly brought into the scientific administration of early breast melanoma. APBI, actually, includes a variety of various options and ways that come with brachytherapy, intraoperative, and exterior beam strategies. there's presently no unmarried resource that describes those options and their scientific implementation. this article is a concise instruction manual designed to help the clinician within the implementation of APBI. This contains a evaluate of the rules that underlie APBI, a realistic and designated description of every approach for APBI, a evaluation of present medical result of APBI, and a assessment of the occurrence and administration of remedy comparable complications.
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Extra resources for Accelerated Partial Breast Irradiation: Techniques and Clinical Implementation
Int J Radiat Oncol Biol Phys 57:1247–1253 Vicini FA, Kestin LL, Goldstein NS (2004) Deﬁning the clinical target volume for patients with early-stage breast cancer treated with lumpectomy and accelerated partial breast irradiation: a pathologic analysis. Int J Radiat Oncol Biol Phys 60:722–730 Vicini F, Winter K, Straube W, et al.
Currently, there are four principal methods of APBI: (1) multicatheter brachytherapy; (2) balloon-based brachytherapy (MammoSite Radiation Therapy System, RTS); (3) external beam three-dimensional conformal radiotherapy (3D-CRT), and; (4) intraoperative radiotherapy with electrons or 50 kV photons. The experience with intraoperative treatment has centered on Milan, Italy (electrons) and London, England (50 kV photons) (Veronesi et al. 2001b, 2003; Vaidya et al. 2001a,b, 2004). Most long-term clinical experience with APBI has been accumulated with multicatheter brachytherapy, MammoSite RTS, and 3D-CRT.
2002, 2005; Vicini et al. 2002) German–Austrian Phase II trial (Strnad et al. 2004; Ott et al. W. Arthur et al. 2 Who Is a Candidate for APBI? 3 Published guidance on selection criteria—successful experiences with >5-year follow up Institution William Beaumont Hospital (Vicini et al. 2003b, 2007a) Tufts/Brown Universities (Wazer et al. 2002; Kaufman et al. 2007) RTOG 95-17 (Arthur HDR et al. 2008) LDR Budapest, Hungary (Polgar et al. 2004) Phase I/II Trial Budapest, Hungary (Polgar et al. 2007) Phase III Trial No.