Download Anatomy of a Scientific Discovery: The Race to Find the by Jeff Goldberg PDF

By Jeff Goldberg

In overdue 1973, scientists John Hughes and Hans Kosterlitz spent nearly all of their time in an underfunded, imprecise, and cramped laboratory in Aberdeen, Sweden. whereas engaged on the brains of pigs, the duo stumbled on a nonaddictive narcotic chemical that they was hoping to later locate in human brains. in the event that they may well isolate this chemical in people, possibly they can have the opportunity to aid the realm start to heal itself. Hughes and Kosterlitz’s examine may necessarily cause them to become aware of endorphins, the body’s personal average morphine and the chemical that makes it attainable to consider either discomfort and pleasure.

Announcing their findings to the clinical global thrust Hughes and Kosterlitz within the highlight and made them celebrities. quickly, scientists world wide have been swiftly studying the human mind and its endorphins. In many years’ time, they might use the team’s preliminary study to hyperlink endorphins to drug habit, runner’s excessive, urge for food keep watch over, sexual reaction, and psychological health problems resembling melancholy and schizophrenia.

In Anatomy of a systematic Discovery, Jeff Goldberg describes Hughes and Kosterlitz’s lives sooner than, in the course of, and after their old and clinical leap forward. He additionally takes a glance on the greater photo, revealing the brutal festival among drug businesses to discover the way to profit from this huge discovery.

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Extra resources for Anatomy of a Scientific Discovery: The Race to Find the Body's Own Morphine

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It was not, however, the sort of work that made one famous. In fact, to all but a small circle of serious drug researchers in Great Britain and America, his twenty-year romance with the guinea pig ileum was something of a joke, a throwback to turn-of-the-century methods. Medical students at the university had nicknamed him “Mr. ” What it meant was so startling that even Kosterlitz still distrusted his conclusion, which remained known only to his closest colleagues. In the early 1960s—ten years before Hughes’s trips to the slaughterhouse began—Kosterlitz had predicted that morphine worked by imitating a chemical already in the body, an endogenous opiate.

They discovered that the drug was active only on a small locus of nerve cells in the brain and that these morphine-sensitive sites were, curiously, also located in the PAG—in exactly the same regions that later became associated with stimulation-produced analgesia. “That clinched it,” Akil said. ’” During the fall of 1971, Akil decided to investigate the narcotizing action of brain stimulation as if it were a narcotic, seeing if she could reverse the SPA effect with nalorphine, an “antagonist” drug known to effectively block the effects of opiates.

ISBN: 978-1-62636-193-5 Printed in the United States of America TABLE OF CONTENTS Introduction to the Twenty-Fifth Anniversary Edition Slaughterhouse Days Brain Soup Locks and Keys Substance X Breaking the Code Alpha, Beta, Gamma The Madness Factor The Endorphin Business Families Rats and Runners The Symphony and the Orchestra Index INTRODUCTION TO THE TWENTY-FIFTH ANNIVERSARY EDITION In the mid-1970s, the discovery of a family of molecules in the body called endorphins, which behaved exactly like narcotic drugs, captivated the popular as well as the scientific imaginations.

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