Download Introduction to Proteomics: Tools for the New Biology by Daniel C. Liebler PDF

By Daniel C. Liebler

Univ. of Arizona, Tucson. Pocket-sized creation to new proteomic applied sciences and knowledge mining instruments. comprises widely used examples illustrating very important proteomics purposes and compares the benefits and downsides of other proteomic instruments and methods. Hardcover, softcover additionally on hand.

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Extra info for Introduction to Proteomics: Tools for the New Biology

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Misek, D. , et al. (2000) Isoelectric focusing nonporous RP HPLC: a two-dimensional liquid-phase separation method for mapping of cellular proteins with identification using MALDI-TOF mass spectrometry. Anal. Chem. 72, 1099–1111. Washburn, M. , and Yates, J. R. (2001) Large-scale analysis of the yeast proteome by multidimensional protein identification technology. Nat. Biotechnol. 19, 242–247. 1. Why Digest Proteins? Modern MS instruments are capable of measuring the molecular weights of intact proteins with a fairly high degree of accuracy.

Complete genomic sequences of several organisms have been completed and these data have allowed analysts to predict the products of all the organism’s genes. Moreover, based on the predicted amino acid sequences of each gene product, these proteins have been classified on the basis of the domains and sequence motifs they contain. For example, 119 of the genes of the Saccharomyces cerevisiae genome encode proteins with eukaryotic protein kinase domains, whereas 47 others encode proteins with C2H2-type zinc-finger domains.

Moreover, based on the predicted amino acid sequences of each gene product, these proteins have been classified on the basis of the domains and sequence motifs they contain. For example, 119 of the genes of the Saccharomyces cerevisiae genome encode proteins with eukaryotic protein kinase domains, whereas 47 others encode proteins with C2H2-type zinc-finger domains. Comparisons of domain-sequence characteristics with genomic sequences reveals many other protein types encoded in an organism’s genome.

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